Bones, genes and fractures

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Bones, genes and fractures

Osteoporosis is a complex disease characterized by a reduction in bone mass with associated bone microarchitectural deterioration and a high risk of fractures. Although environmental factors like nutrition and mechanical load, as well as lifestyle, may influence the development of the disease, family and twin pair studies have suggested that there is also a strong genetic component in a predisp...

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Fractures of the Carpal Bones Excluding

Carpal fractures excluding the scaphoid can cause morbidity that is disproportionate to their incidence because they are easily overlooked and are often harbingers of a wider wrist injury. Failure to recognize a more global injury pattern can result in undertreatment and permanent wrist dysfunction. Diagnosis requires a high index of suspicion, familiarity with carpal topography to guide the ph...

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[Fractures of the sesamoid bones of the hallux].

Over a period of one year we treated nine fractures ofhe sesamoid bones of the hallux, five of which were in the medial sesamoid. All patients had symptoms on exercise, but only one had a recent history of injury. The mean age of the patients was 27 years (17 to 45) and there were six men. The mean duration of symptoms was nine months (1.5 to 48). The diagnosis was based on clinical and radiolo...

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Treatment of pathological fractures of the long bones

Bone metastases of the long bones often lead to pain and pathological fractures. Local treatment consists of radiotherapy or surgery. Treatment strategies are strongly based on the risk of the fracture and expected survival.Diagnostic work-up consists of CT and biopsy for diagnosis of the primary tumour, bone scan or PET-CT for dissemination status, patient history and blood test for evaluation...

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The Prophylactic Effect of Methyl Prednisolone Sodium Succinate against Fat Embolism in Long Bones Fractures

In this prospective study the effect of low dose methylprednisolone succinate (10mg/kg) on the incidence of fat embolism syndrome and isolated arterial hypoxemia in 99 patients with long bone fracture (52 control and 47 steroid-trated subjects) was studied. Frequency of fractures among the selected patients was as follows: femoral fracture 52.5%, tibial fracture 36.4%, both femoral and tibial f...

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ژورنال

عنوان ژورنال: EMBO reports

سال: 2002

ISSN: 1469-221X,1469-3178

DOI: 10.1093/embo-reports/kvf003